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    August 09, 2022 41 min read


    What Is CBD Cream? Your Guide To CBD Topicals

    CBD is applied to the body through topical products like CBD creams, lotions, massage oils, and roll-ons that do not penetrate below the top skin. You can also use transdermal CBD products like patches that go beyond the top layer and interact with the endocannabinoid system to exert the claimed benefits. Transdermal and topical CBD products may help you, but you need a guide that details all you need to know about them.

    Transdermal and topical CBD products are useful when you want to benefit from CBD, specifically in the external parts. Transdermal CBD products like patches may well go below the skin and interact with the endocannabinoid system, but not the bloodstream. Early studies show that CBD topical and transdermal products may help with pain and inflammation. It's no wonder that people use them for arthritis, shingles, jaw pain, neck pain, and related issues. How much CBD topical should you apply for back or neck pain? What should you look for when buying CBD topicals? How do CBD creams and other topicals work for pain? Do topical CBD products make you feel ‘high?’ and can they show up in drug tests? This 101 guide to CBD topicals answers all these questions. Peer into it for such well-researched information.

    What Is CBD?

    This section helps you know what CBD is before looking at CBD topicals. There is much said about CBD, most of which leads to confusion? According to Bauer et al. (2020) and Massi et al. (2006), CBD is the non-psychoactive chemical compound in hemp and other cannabis plants. Non-psychoactive means that it does not make you 'high.' People take CBD through different delivery methods, including topicals, without fearing the 'high' or stoned effect.

    CBD grows in craze every day, and more and more people are embracing it. According to an article by Gill (2020) on the Consumer Report Survey website, more than one-third of the US population uses CBD for various reasons, including pain, inflammation, and stress. Although CBD studies are limited, and there is insufficient evidence to show that CBD can treat or cure any medical condition, people are enthusiastic about exploring the claimed benefits of CBD. In fact, the future looks bright with CBD.

    CBD and THC: What Is the Difference?

    If you are a CBD fan, you probably have heard about THC, a close cousin of CBD. In fact, when reading labels for any CBD product, you will likely find something about THC, say the total THC percentage of the product. Yet, many people are paranoid at the slightest mention of THC. What is THC, and if anything, the problem with it? What is the difference between CBD and THC?

    According to Schlienz et al. (2018), THC is the psychoactive compound in hemp, marijuana, and other cannabis plants. Cannabis plants of different strains have more than 140 chemical compounds called cannabinoids, and THC is the psychoactive one. Being psychoactive, Schlienz et al. (2018) reported that THC is intoxicating and can cause psychosis. Many other studies agree with these findings. The other significant difference between CBD and THC is their percentage concentrations in different plants. For instance, CBD is more abundant in hemp (20%- 30%), while the same plants only have little THC (less than 0.3%) because of genetic modification. Meanwhile, marijuana plants boast high THC contents (25%- 35%), while they have relatively low amounts of CBD (15% or less).

    Where Does CBD Come from?

    Have you ever wondered where the CBD in the different CBD products comes from? Is CBD natural or synthetic? While cannabinoids can be synthesized, most cannabinoid products are made from natural options. For instance, CBD is natural and comes from hemp plants. Of course, marijuana plants also have CBD, but most CBD companies focus on hemp plants for extracting the cannabinoid. The Farm Bill was passed in 2018, making hemp and its products federally legal, provided they have less than 0.3% THC. For this reason, hemp plants make better sources of the industrial CBD featured in various products.

    What IS CBD Oil?

    CBD is a compound, and its nature is so unique that the body cannot absorb it as it is. Manufacturers mix it with other ingredients and base it on another compound that the body can absorb, taking CBD onboard in the process. CBD oil is a dilute form of CBD. It features the cannabinoid placed in an oil base. Most CBD brands have CBD oil-based in MCT coconut, olive, or hempseed oils for the body to take advantage of the cannabinoid and explore the benefits linked to it. According to Watt & Karl (2017), CBD oil is therapeutic and has many health benefits, but more studies are needed to confirm this.

    You can explore the benefits of CBD oil by taking it orally or sublingually. Oral intake involves placing CBD oil drops on the tongue and swallowing them as you would for any liquid product. It requires a little patience to feel the effects of CBD oil after oral intake since the cannabinoid goes in through the digestive system. The longer it takes to get to the bloodstream, the more you have to wait for the effects. You can also take CBD oil sublingually, where you place the drops of the cannabinoid below the tongue, allow 30- 60 seconds to elapse, and swallow the rest. While both methods feature direct interaction of CBD with the tongue and involve feeling the bitterness and earthiness of CBD, sublingual intake ensures CBD gets to the bloodstream fast and you can look forward to the effects equally fast. The region below the tongue features multiple blood vessels that ensure CBD reaches the system fast.

    What Are CBD Topicals?

    As the name suggests, CBD topicals are products with CBD as a core ingredient and which are applied to the top layer of the skin. Lotions and roll-ons are examples of topical products, and CBD topicals are equally diverse. You can explore CBD creams, lotions, roll-ons, and massage oils, which are topical products.

    Like other CBD products, CBD topicals are fast becoming popular, and there is so much to explore. According to Watt & Karl (2017), CBD oil is therapeutic, and since CBD topicals feature CBD, many people are after them for the claimed therapy. More studies are needed to set facts right from fiction and to confirm that CBD can deliver as much as claimed. CBD topicals are like CBD oil, only that they are applied to the external body parts. Besides, their mode of applications and operations differ.

    What Is Transdermal CBD?

    Transdermal and topical CBD products go hand-in-hand since their application methods are more or less the same. Still, the two differ subtly. How so? CBD topicals are topical per se, i.e., their benefits are only felt on the top layer of the epidermis and do not go beyond. However, CBD transdermal products go beyond the top layer and interact with the internal system.

    According to Mechoulam & Parker (2013), the human body has an endocannabinoid system (ECS) that interacts with the brain and the critical body organs to ensure all the crucial processes take place as intended. The study also noted that CBD, as in transdermal CBD products, is a cannabinoid and interacts with the ECS for the claimed benefits. So far, that's what studies say about the application and working of CBD, which also applies to transdermal CBD products. Nonetheless, more studies are needed to prove this right. Meanwhile, it is worth noting that while transdermal CBD products go beyond the top layer of the skin, it does not interact directly with the bloodstream.

    How do CBD Topicals and CBD Oil Compare?

    CBD fans who have had the experience of CBD oil and CBD topicals alike would tell some differences between the two. Yet, if you are new to the CBD bandwagon, you may not know much and thirst for the comparison between CBD oil and CBD topicals and transdermal products. For the most part, anyone can tell minor differences by the look of the eye.

    For a start, CBD oil is liquid-based, i.e., it has a carrier oil as the base. Meanwhile, CBD topicals and transdermal products may also be based on oils but are not liquid, except for CBD massage oils. The other difference between CBD oil and CBD topicals is how the two are taken. You take CBD oil orally or sublingually, yet that's not the same for topical or transdermal CBD products applied topically or transdermal on the external body parts.

    Do CBD topicals or oils differ in effects? Not quite much. According to Vučković et al. (2018), CBD oil helps with chronic pains, including cancer, fibromyalgia, and neuropathic pains. Elsewhere, Eskander et al. (2020) stated that CBD in topical products can help with back pain. Both studies require scientific evidence to prove them right, they all point to the pain-relieving properties of CBD.

    CBD oils and CBD topicals may vary in how long they take to work and how long the effects last. Since CBD oil is taken orally or sublingually, with the latter being more effective, you look forward to the effect in no time since the blood vessels under the tongue facilitate fast delivery of the cannabinoid to the body. Meanwhile, topically applied CBD may take longer to start working. It might take 30-minute patience to feel the effects of CBD in CBD oils, but topicals may take as long as 1 hour to express effects.

    CBD oil is great for bioavailability, and the effects will manifest in no time. Does this mean that it takes the day's cake and ticks all the boxes? No, CBD oil and tincture are bitter and earthy. While some CBD fans like the earthiness, most users struggle to contain the taste. Meanwhile, you don't take CBD topicals orally, so you don't have to bear the bitterness. Many people are increasingly interested in CBD topicals for the lack of the need to taste the products. Ultimately, no CBD products are better than the other, whether oils or topicals and the ultimate choice depends on your interest.

    How Do CBD and CBN Differ?

    CBD and THC are the commonest cannabinoids, and the two have been more extensively studied than others. The other cannabinoid you may want to know about is CBD (cannabinol). It is linked to THC (tetrahydrocannabinol), which disintegrates to form CBN, and the two are used together in many studies. Still, the two vary in properties. How do CBD and CBN compare? Does CBN have therapeutic effects? Here is what a few selected studies say about CBN.

    According to Karniol et al. (1975), CBN can help with sleep. The study looked at 5 participants taking CBN and recorded that they all experienced significantly better sleep. Murillo-Rodriguez et al. (2014) pointed out to the sleep benefits of CBD, showing that it improves sleep quality. According to Wong & Cairns (2019), a CBD-CBN mixture reduced pain in myofascial rats better than CBD alone, suggesting that combining the two cannabinoids may help CBD perform better. Elsewhere, Weydt et al. (2005) reported that CBN fought amyotrophic lateral sclerosis (ALS) in rats, pointing out to neuroprotective properties of CBN. Zueir & Burstein (2016) reported that CBN can fight inflammation. Similarly, Hammell et al. (2016) recorded that CBD helps with inflammation. CBD and CBN seem to have various benefits, though the latter has not been extensively studied. Besides, most studies on CBN benefits feature animals. However, CBD studies have cut across, even taking human beings onboard.

    Isolate, Full- and Broad-Spectrum CBD Topicals: How Do They Compare?

    Isolate, full, and broad-spectrum formulations are closely linked to CBD products, including topicals. All CBD items bear one of them. You need to know what they are and how they differ if you are considering joining the CBD bandwagon and want to specialize in topicals. For a start, they are CBD formulations, with the main difference being in their compositions.

    CBD in any CBD product occurs in three forms based on the presence or absence of THC, additional cannabinoids, terpenes, and flavonoids. For example, full-spectrum CBD features CBD alongside all the cannabinoids in the hemp plants, terpenes, and flavonoids. It also has the psychoactive THC, although the percentage varies depending on the manufacturer. Most CBD fans like full-spectrum CBD topicals because of the full entourage effect. According to VanDolah et al. (2019), the effect comes from multiple compounds. If you want nothing to do with THC in the CBD topicals, you need not go for full-spectrum CBD products.

    Broad-spectrum formulated CBD products are more or less similar to full-spectrum CBD in composition, though they differ subtly. Like full-spectrum CBD, broad-spectrum CBD has terpenes, cannabinoids. All other cannabinoids in hemp plants but does not have THC. Consequently, it is great for CBD users who want to enjoy multiple compounds in CBD but want nothing to do with THC.

    Isolate-based CBD products are pure and have no other compounds than CBD. They are typically 90%- 99.9% pure and are featured in almost every CBD delivery method, including topicals. If all you want is pure CBD without additional compounds, isolate-based CBD topicals will serve you well. Remember that they are pure CBD, so you don't expect the full entourage from them.

    How Does CBD Interact with Endocannabinoid System and the Body?

    Much is yet to be understood about CBD, and one of the things new users are yet to fully know is how CBD works and how it interacts with the body. Zou & Kumar (2018) stated that the human body has an endocannabinoid system (ECS) related to critical body processes, including sleep, muscle contraction, appetite, satiety, and pain modulation. According to the study, the ECS comprises endocannabinoids like anandamide (AEA), endocannabinoid receptors (CB1 and CB2), and enzymes that play a role in making the endocannabinoids.

    According to Eskander et al. (2020), the body produces endocannabinoids, which can also be damaged in the body. The endocannabinoid receptors are all over the body, especially in the critical organs linked to the functions they control. The CB1 receptors are mostly found in the central nervous system, while the peripheral nervous system has CB2 receptors. Mechoulam & Parker (2013) reported that the destruction of the endocannabinoids interrupts critical processes, leading to an imbalance, and that's where cannabinoids like CBD and THC come in.

    How exactly the cannabinoids interact with the ECS to help with body functions and processes is not well understood. However, Zou & Kumar (2018) stated that THC binds to the receptors to offset any imbalance, setting critical processes on track. Still, how CBD interacts with the ECS remains a mystery that only more scientific studies will unveil. Does CBD bind to the ECS receptors? Does it prevent endocannabinoids from being damaged? These are just theoretical ideas, and only more studies will prove them true or nullify them.

    How Do CBD Topicals Work for Pain?

    According to Eskander et al. (2020), CBD topicals can help with back pain. Studies like these see potential in CBD, and many people now opt for CBD topicals for pain. Do you want to join the CBD regime and apply CBD topicals to the affected parts of your body for pain? You definitely want to know how CBD topicals like creams, lotions, body massage oils, and roll-ons work.

    Much is yet to be revealed about CBD, including CBD topicals. Unlike CBD ingestible products, the topicals do not interact directly with the bloodstream. For instance, applying CBD creams or lotions to your skin ensures the cannabinoid does not go beyond the top layer of the epidermis and that it operates within the borders. The ECS discussed above then comes to play. According to Zou & Kumar (2018), ECS receptors are all over the body, including on the skin. The applied CBD interacts with the receptors, and their reaction leads to the benefits. Still, more studies will tell if the ECS is real and if it interacts with CBD in this manner.

    CBD patches are linked to topicals, but they are more transdermal than topical. They have many adjuvants that make them effective, and unlike CBD topicals like creams, they go beyond the top layer of the epidermis and reach the derma below. Transdermal CBD products do not get to the bloodstream. Rather, they interact with the ECS receptors, only that they go for receptors deeply entrenched in the skin. Because of depth they go, transdermal CBD products may be more effective than CBD topicals. This is evident in how fast the effects manifest, making transdermal CBD delivery almost as effective as CBD sublinguals.

    What Are the Side Effects of CBD Creams?

    If you want to take CBD topicals, you don’t want to ignore the concern of their side effects, especially if you have sensitive skin. Is there a big deal with CBD creams, or can you take them without fearing a thing? According to Corroon & Phillips (2018), CBD has a good safety profile, suggesting that the cannabinoid is well-tolerated in most cases. Yet, that’s not always the case, and sometimes CBD intake might not go well with the user. For instance, Bass & Linz (2020) documented a case in which a man ingested 375 mg CBD from a whole packet of gummies and suffered toxicity. He became unconscious, and his speech blurred, after which he was taken to the hospital and recovered a day after. Is there anything you need to know about CBD creams as far as the side effects of the topical products are concerned?

    According to Iffland & Grotenhermen (2017), CBD is linked to diarrhea and tiredness, and the latter may be true for CBD creams, especially if it has become part of your daily regimen. Is that all? Huestis et al. (2019) reported that CBD, especially in animals, may lead to complications such as interrupted reproduction, embryo-fetal mortality, weight alteration, and hypertension. It is not clear if CBD topicals are attributed to any of these, but more studies are needed to set things straight. If you have sensitive skin, you may prepare to suffer allergic reactions with CBD creams, especially if you respond negatively to other topicals, including those lacking in CBD as an ingredient.

    Can CBD topicals lead to contact dermatitis? Contact dermatitis is a dermatological problem in which sensitive skin responds negatively to some products. It leads to red rashes in the contact area, which may go fast or last long. No studies have shown that CBD creams may trigger contact dermatitis. Take care and know how to handle the rashes should they come. Sometimes, you might need to discontinue CBD use if you confirm that the cannabinoid is beyond the skin problem.

    CBD Topicals Vs. CBD Edibles: How They Compare, and Which One Should You Go for?

    Many CBD fans, novices, and veterans alike find CBD edibles great for their taste and flavors. CBD edibles are diverse and feature the CBD class with many products you would want to explore if you are a CBD fan. Are CBD edibles better than CBD topical? No, the various CBD delivery methods allow you to explore CBD in different ways, and none is better than the other. Still, CBD edibles and CBD topicals vary widely, with each having pros and cons you must deal with.

    CBD edibles promise variety and taste without overemphasizing their varieties, yet they don't tick the box for bioavailability. They have to be digested and CBD released into the bloodstream before you can feel their effects. CBD topicals do not feature taste. However, topical beauty CBD products like lipsticks might have flavors. You need patience for CBD topicals to produce results. While this is also true for CBD edibles, topicals take even longer to produce the desired effects. CBD topicals sound better for you, especially if you want CBD but not its interaction with the bloodstream.

    Can CBD Be Absorbed Through the Skin?

    CBD oils, edibles, and vapes allow the cannabinoid to be absorbed into the body. However, many wonder if that's the case for all CBD products. Can CBD in CBD topicals and transdermal products be absorbed through the skin? Generally, CBD gets to the body through the skin. The extent varies depending on the product you have specialized in.

    CBD topicals designed for the top layer of the epidermis will be absorbed through the skin but will not go beyond the epidermis. Most topicals and ointments will only go as far as the top layer of the epidermis. Meanwhile, transdermal CBD products like patches on the skin tend to be more effective than topicals. The application sees them go beyond the top layer of the epidermis and reach as far as the derma below. Consequently, they help deliver the cannabinoid to the body fast, and the effects may manifest in no time. Transdermal CBD products are as effective as CBD sublinguals. Even though they are not commonly used, they are great for delivering the cannabinoid to the body. If all gets worse and you want CBD vehicles that see the effects come fast, you may consider transdermal CBD products like patches.

    Will CBD Topicals and Transdermal CBD Products Make You ‘High’?

    Most people would like to explore THC, but they fear it for the 'high' or stoned effect. According to Schlienz et al. (2018), THC is psychoactive and intoxicating, putting many away. Although CBD is non-psychoactive, you may wonder if the transdermal and topical products featuring the cannabinoid will get you 'high.' It is relieving to know that you will not feel 'high' or stoned after applying CBD transdermal and topical products to a localized area. No matter the CBD formulation you specialize in, don't fear the 'high' effect. The THC in full-spectrum CBD topical may get passed the skin if you apply patches, but it does not get as far as the brain. If it did, you would expect to feel 'high' after applying the topicals.

    What about other CBD products? Will they make you 'high' and subject you to intoxication? Generally, any CBD delivery method should not make you stoned. However, the effects of CBD products that interact with the bloodstream largely depend on the CBD formulation. The type of CBD in the product matters, and whether there are additional hemp compounds also comes to play. For instance, buying isolate-based or broad-spectrum CBD from a reputable brand helps you get THC-free products that should not make you 'high.' Meanwhile, full-spectrum CBD products may or may not make you 'high' depending on the source and the THC percentage.

    Reputable brands dealing in full-spectrum with less than 0.3% THC will give you products that give the desired effects without making you ‘high.’ However, full-spectrum CBD products with high THC content might leave you stoned. The low-quality CBD companies might not label CBD products accurately. You may mistake a high-THC CBD product for a THC-free product and get 'high' from them. Always focus on quality and THC-free formulations if you want CBD but not the 'high' effect.

    Will CBD Topicals Show in a Drug Test?

    Although many want to explore THC-filled CBD products, they go slow for fear of failing drug tests. People take CBD drug tests from time to time, especially if they work in the sports industry or are changing jobs. Will CBD topicals show up in drug tests and make you fail? Is there anything you need to care off? If you take isolate-based or broad-spectrum CBD topicals from reputable brands that accurately label products, you definitely will not fail a drug test. Is that the case with full-spectrum CBD topicals?

    Full-spectrum CBD topicals have CBD but also feature additional compounds, including terpenes, flavonoids, THC, and all other cannabinoids. Since they have THC, many think they will show up in a drug test since the tests detect THC or its metabolites. Well, CBD topicals will not show up in drug tests regardless of the formulation. How so if the CBD and THC in the full-spectrum CBD topical get absorbed through the skin! While this is the case, the psychoactive THC does not get into the bloodstream and the brain and will not show up in tests. For this reason, you can use CBD topicals confidently without fearing failing drug tests, regardless of the CBD formulation.

    What Do CBD Creams and Topicals Do?

    According to Watt & Karl (2017), CBD is therapeutic and helps manage Alzheimer's disease. CBD topicals and transdermal products deliver CBD, and many look up to them for some therapy. Do CBD topicals measure up? What can they do? Here is what studies claim that CBD topicals can do. Still, more research on CBD is needed, and while some findings may see great potential in the cannabinoid, you should not take them as medical advice or CBD recommendation for treating or curing a condition. Remember, Epidiolex is the only CBD/THC- produced product the FDA has approved for medical purposes, especially in managing Lennox-Gastaut and Dravet Syndromes, two rare forms of epilepsy.

    a)      CBD Topicals May Help with Back Pain

    Many people suffer back pains, and while the pain is acute in some people, others have to manage it throughout their lives. Back pains and inflammation are twinned and usually occur together, especially in the internal organs. Meanwhile, the emphasis on natural products increases and the craze around CBD oil for pain is here to stay. Can CBD topicals cure or treat your back pain? Eskander et al. (2020) reported that CBD effectively helped lower back pain. The study mentions that CBD interacts with the endocannabinoid system to result in such effects. Still, more studies are needed to support the findings before recommending CBD topicals for pain, especially in the back.

    b)      CBD Oil May Help with Peripheral Neuropathy

    Peripheral neuropathy is a condition in which the nerves become increasingly tender. They may cause pain and also become inflamed, limiting your activity. Can you look up to CBD, especially topicals, to manage the neuropathic condition? Maybe; it's your choice. According to Vučković et al. (2018), CBD oil has pain-relieving properties and fights cancer, neuropathic, and fibromyalgia pains. Besides, Xu et al. (2020) also reported that CBD use may help relieve neuropathy. Consequently, does not promise to heal, cure, or treat your peripheral neuropathy. Still, it promises to help you manage the symptoms that accompany the condition. Because CBD studies on neuropathy are limited, do not discontinue your medication and focus on CBD topicals and hope to get better.

    c)       CBD Topicals May Help You Relax

    Pain, anxiety, stress, and inflammation are a few reasons a person may not relax. If you are anxious and think a lot, you may not relax. Besides, excruciating pains do not give you the peace you need to sleep. Can you depend on CBD topicals to help with any problem, ultimately finding relaxation? Generally, CBD topicals or other deliverable methods are not relaxation supplements. However, studies see potential in the cannabinoid battling the causes of lack of relaxation, helping you feel better. For instance, Hammell et al. (2016) reported that CBD can fight inflammation, and if your skin itches, making it hard for you to relax, you can benefit from such. According to Mlost et al. (2020) and Schilling et al. (2021), CBD can reduce pain and improve your condition if your uneasiness is caused by pain.

    d)     CBD Topicals May Help You Sleep Better

    Insomnia and other sleep problems are rampant, and people suffer poor sleep quality today more than ever. Many factors could contribute to the lack of sleep, with pain, inflammation, stress, and depression being among them. Can you bank on CBD topicals to help you sleep? According to Baron et al. (2018), CBD can reduce the intensity of headaches and migraines. The study also added that the cannabinoid may help with pain. With reduced pain, you can catch sleep and sleep for longer. Besides, Murillo-Rodriguez et al. (2014) reported that CBD can improve one’s sleep since it influences the sleep-wake cycle and the functioning of the circadian rhythm. While CBD does not promise to treat insomnia, applying CBD creams to your head might help you improve your sleep a bit. Still, we look forward to more studies on CBD topicals for sleep.

    e)      CBD Topicals May Fight Eczema, Acne, and Psoriasis

    Acne is one of the commonest dermatological issues, and many have to deal with it at one point in life. For some, it can go away in childhood, while others have to nurse it into adulthood. Acne is not the only skin problem; eczema and psoriasis are also in the picture. Can CBD topicals help with these skin menaces? According to Schuelert & McDougall (2011), CBD can fight inflammation. Although the study looked at the anti-inflammatory properties of CBD in animals, it reveals that humans may also benefit from them. Besides, Hammell et al. (2016) documented a case in which transdermal CBD helped arthritic rats see significant improvement in pain and inflammation. These properties of CBD may help with skin conditions like acne, though there is  need for more studies with enough evidence to prove that topical CBD will remedy skin issues. The American Academy of Dermatology reports that people with skin issues have significantly benefited from the promising skin-related benefits of CBD topicals.

    f)       CBD Creams May Help Manage Arthritis

    Arthritis is a medical condition in which bones and joints disintegrate, pain, and may be inflamed. There are two forms of arthritis, osteoarthritis and rheumatoid arthritis, which lead to pain and inflammation despite affecting different areas. Can you apply CBD creams on the joints to find relief for arthritis? According to the Arthritis Foundation (Feb 2018), people can and have benefited from topical CBD. Hammell et al. (2016) reported that CBD has anti-inflammatory properties that benefited rats with arthritis. If you choose CBD topicals for inflammation, take it slow, specifically if you have sensitive skin.

    g)      CBD Creams and Topicals May Help You Manage Jaw Pain

    People who have suffered jaw pain agree that it is one of the worst pains. Depending on the degree, you may not be able to talk, eat, or even turn your head. Yet, not every pharma-grade medication helps with such pains, and if they do, they may be linked to side effects in the future. Can you look to CBD topicals to manage jaw pain? Studies promise a lot. For instance, Nitecka-Buchta et al. (2019) reported that CBD significantly reduced jaw pain. Vučković et al. (2018) reviewed various CBD studies and concluded that CBD can help with pain. Nonetheless, we cannot ignore the fact that CBD studies have their fair of challenges. Until research narrows down to CBD topicals for jaw pain, take it slow with the cannabinoids.

    h)      CBD Topicals May Help with Workout Recovery

    You have come from your exercise routine and have suffered injuries, minor or major. Will CBD help you? Generally, CBD boasts many benefits, as far as the existing research papers can show. According to Mauer et al. (2020), most such studies have not focused on the athletic population. Nonetheless, sportspeople go for CBD topicals to manage the pain and inflammation that come with the injuries. How efficacious is CBD topical for pain and inflammation? According to Schuelert & McDougall (2011), topical CBD reduces inflammation. Schilling et al. (2021) established that CBD can fight pain. Although you cannot take care of all the sports injuries with CBD topicals, they may help trim down the inflammation and pains accompanying them.

    How Do CBD Topicals and CBD Vapes Compare?

    CBD vapes are climbing the popularity ladder like other CBD products. In fact, most veterans like them for their high bioavailability. This is because they feel CBD have effects only moments after vaping. How do CBD vaping and CBD topicals compare? Is any better than the other? No CBD product is better than the other. The varieties are there to help people get what meets their needs. Of course, each method of taking CBD to the body has pros and cons that you weigh as you choose what to settle for.

    CBD vaping means inhaling CBD e-liquid. It is the fastest way of delivering CBD to the body, and so many like it. Still, vaping may lead to lung irritation. According to the Center for Disease Control and Prevention (CDC, 2020), there are more and more hospitalizations of CBD vaping and cigarette smoking. Vaping CBD might deliver the effects fast, but the side effects are detrimental in the long run. Meanwhile, CBD topicals may force you to wait for the effects to manifest. However, there are no documented cases of topical or transdermal CBD causing cancer.

    How to Use CBD Creams, Lotions, and Salves

    Most people in the sports world like CBD topicals for one reason or another. According to Mlost et al. (2020), CBD can fight pain. Everyday life presents many hazards, and whether you are working or at home or going to work, you may get injured. CBD topicals, salves, and creams rising can be applied to the affected area. How do you use CBD topicals for pain?

    CBD is easy to use, and this is one of its strongholds. To apply the topical CBD product, all you have to do is clean the surface or the affected area and pat it dry. With the surface clean and dry, apply a little CBD cream or salve or the massage oil on the affected area and rub continuously but gently. You may want to add a little of the product in question after 5 minutes of massaging and keep up the process until you feel the effects. Most CBD products applied topically will follow the same procedure. This shows that using CBD is no rocket science and needs no special skills.

    Why Applying Topical CBD Products Might Be Challenging

    While the experience with CBD topicals is not an extremely difficult one, it can also be challenging. Remember, the FDA does not regulate the CBD industry and does not take responsibility for anything. It does not recommend how much CBD you should take, except for Epidiolex, which is the only CBD-produced drug approved for two rare forms of epilepsy. What does this imply?

    The CBD manufacturers research and recommend CBD dosages that they think are ideal for any CBD product, including the topicals. Yet, the results are not the same for all users, and while one person may need only a little CBD cream to feel better, another might need to add some more to feel the desired effects. Consequently, dosing CBD topicals is challenging, and sometimes you may waste the product as you apply more and more to feel the effects. Still, we look forward to a bright future when much will be clear for CBD.

    Is CBD Creams (and Other CBD Topicals) Legal?

    Even as many people embrace CBD and join its bandwagon, its legality remains a key concern. While some world regions have legalized it with a few restrictions, others have strict CBD and cannabis laws and view any CBD product as illegal. Are CBD creams and other topicals legal? Much depends on your locality.

    When the Farm Bill was passed in 2018, hemp and its extracts were pronounced federally legal, as long as they had less than 0.3% THC. Therefore, CBD products, including topicals, are federally legal in the US, provided they are derived from hemp and have less than 0.3% THC. Still, state CBD laws and what is legal in one state may land you in jail in another state. Some states deem CBD topicals legal, regardless of the formulation and the THC percentage. Still, others consider hemp-derived CBD topicals legal but place restrictions that CBD brands must meet. Meanwhile, CBD topicals are illegal in other states.

    Are CBD topicals legal in the UK, Asia, and Africa? The UK considers hemp-derived CBD products with less than 0.2% THC legal. Provided your hemp-derived CBD cream or roll-on does not exceed the THC threshold, you can use or possess it without any fear. Meanwhile, CBD remains illegal in many countries in Asia and Africa, and the surest way to know the legal status of the CBD topicals in a country is to research it, as the next section shows.

    Research Your State or Country and Ask for CoA, Which You Should Always Carry Along

    Are you planning to travel with CBD topicals onboard? Research your country or state of interest. CBD laws vary from different countries and states to the others, and you don’t want to rub shoulders with the authorities the wrong way. If you want to the join the CBD bandwagon because of its claimed benefits, research well and get to know how your country or state views the cannabinoid. While some states might allow CBD with partial restrictions, some delivery methods are not allowed. Still, the internet does not lie, and checking your state's or country's CBD laws helps you know what to do.

    If you choose to buy CBD topicals, get a CoA as well. CBD companies are required to conduct 3rd party tests to gauge the contaminant purity of their CBD topicals and other products and also to show the cannabinoid profile. Yet, only the CoA proves a brand has conducted such tests. Given the CoA for the topical CBD product in question, carry it along whenever you go, as long as you have the topical CBD product. When worse gets to worst, the CoA vindicates you, showing that the product does not exceed the set THC thresholds. Other than speaking for you, the CoA helps you know how safe the product in question is and if it is fit for your consumption.

    Consult a Medical Practitioner Before Trying CBD Topicals- Have You Ever Wondered Why?

    According to Schilling et al. (2021) and Hammell et al. (2016), CBD may help fight pain and inflammation. For these reasons, the cannabinoid is getting more popular. Still, you don't want to take any CBD products, topicals included unless you speak to your doctor. Have you ever wondered why?

    Some vets and doctors will hold back from speaking about CBD products or recommending them to patients for every good reason. While the media is full of what CBD can do, we only know a handful about the relatively new cannabinoid. According to Corroon & Phillips (2018), CBD generally has a good safety profile. Yet, that’s not always the case. Bass & Linz (2020) show that CBD might cause toxicity, especially when taken in high dosages. Yet, no regulatory body has taken responsibility for CBD production. One struggle you must prepare for if you choose CBD is to figure out the dosages independently. Are doctors the answer? Where do they even come in?

    Generally, doctors play the role of advisors. While you might have a hard time figuring out the right dosages to administer CBD topicals, you definitely agree that having an advisor by your side makes things better. For the most part, they should know the thresholds for the cannabinoids. Meissner & Cascella (2021) reported that CBD may cause liver damage, and the relationship is more dose-dependent. Although you don’t expect CBD topicals like creams and ointments to react with other medications (they don’t interact with the bloodstream), doctors are better placed to tell you the likelihood of having negative effects of the cannabinoid.

    Where to Buy CBD Topicals

    Do you want to join the CBD bandwagon and have chosen to go for topicals? You might have gone online and typed 'where to buy CBD topicals and creams near me.' The technological advent has done us wonders, and buying anything is easier than you think. You can have CBD topicals made in your country or state (if they have a CBD company), but you can also import them.

    For a start, you can choose to go the in-store way to buy your CBD topicals and get the chance to scrutinize what you want before ordering it. Pharmacies, health food stores, gas stations, CBD brand shops, dedicated CBD shops, and CBD dispensaries are all over and offer CBD products, topicals included. The convenience of walking into the shop and picking what appeals to your eye (and what benefits you) is unmatched.

    If you don't fancy in-stores shopping and can't get enough of online shopping, buying CBD topicals online looks good on you. All you need to do is get a stable internet connection, search CBD websites online, identify your CBD company of interest, research it, and if it is ok with you, order CBD topicals and pay for them. The products are delivered to your doorstep, and you have your best picks. How do online and in-store CBD shopping for CBD topicals compare? Is any better than the other? The two shopping options have pros and cons; all you have to do is weigh them and choose your struggle wisely.

    Pros and Cons of Buying CBD Topicals In-Store

    If you fancy shopping CBD products in-store, you will appreciate that you don't have to worry about delivery fees. You buy the product and choose them from the shelves. Besides, gas stations and CBD outlets offer convenience, especially if you need CBD products so badly but have no time to order the products online. In-store shopping allows you to scrutinize your products before paying for them, and there is nothing as taking home what you are sure about.

    Still, in-store shopping is not all merry, and there are cons you have to deal with. For example, when the CBD outlets stock CBD and THC products alike and put them next to each other, there are high chances of cross-contamination. While you may be paying for THC-free products, they might be contaminated and have THC, making you fail drug tests. Some CBD outlets charge CBD products dearly, and you may pay more than you would for online products. As though that's not enough, most CBD outlets do not have provisions for a money-back guarantee, and once you have bought the CBD topicals, you may not be able to return them and claim refunds should they not meet your expectations. Lastly, buying CBD topicals in-store does not allow you to get satisfactory answers the agents for CBD brands would offer if you shopped online.

    Pros and Cons of Buying CBD Topicals Online

    We all agree that online shopping for topical CBD offers convenience since the orders are dropped at your doorstep, and you often don't need to pay delivery fees. Besides, we cannot overlook how much online shopping for CBD products gives you many options to explore in terms of CBD companies. Yet, you have access to all these privileges without fumbling around and mixing with people during these Covid-19 times. Buying CBD topicals online also allows you to ask the online agents questions and get satisfactory answers since they are mostly experts in the CBD world. Is it all flawless for CBD online shopping?

    If you choose to buy your CBD topicals online, you must factor in delivery fees which turn out to be expensive when buying one product online. Some companies may have discount options, including free delivery, but you can only take advantage of them if you meet a certain threshold. Yet, not every CBD fan makes it up there and might not have enough to dedicate to the CBD topicals and take advantage of the bundled deals. The other challenge of online shopping is that companies sometimes paint a false picture of themselves. How many times have people bought CBD topicals and realized that they are not as good as claimed? Lastly, buying CBD products online, especially from another country, may mean that you have to take care of the liabilities since some brands put it out clearly that they will not take responsibility for any damages. Ultimately, there is no better form of shopping; it's all about weighing the pros and cons and choosing what to contend with.

    What to Consider When Buying CBD Topicals

    Whether you want to buy CBD topicals in-store or online, you need to pay attention to particular aspects. Of course, the best CBD topicals are only theoretical since the CBD world is largely unregulated. While a brand may polish its frameworks, it cannot tick all the boxes. Focus on the following areas when buying CBD creams and other topicals;

    1. Source of CBD; CBD can come from hemp or marijuana, but most brands use hemp-derived CBD to manufacture CBD products and be in line with the 2018 Farm Bill requirements. Choosing such CBD items helps you be confident with your products, knowing that you are not violating any rules.
    2. CBD formulation; CBD topicals come in three formulations; isolate-based, full-, and broad-spectrum options. While none is the best, you need to buy what you understand and are comfortable with.
    • Environmental factors; there are organic and inorganic CBD products, and many opt for the latter since they are relatively safe. They don't feature toxic chemicals from hemp growing to CBD packaging and are better off than the inorganic alternatives.
    1. Reputation; read about the CBD brand of interest online and find out what CBD clients say about their topicals.
    2. Ingredients; while some CBD companies lie about what makes up their topicals, reputable brands will be genuine. The ingredient list helps you know what is in the topicals and clears or confirms the possibility of side effects, especially if you have sensitive skin.
    3. 3rd party testing; the CBD industry is largely unregulated, and only 3rd party tests help you know how good a CBD topical in question is.
    • The presence of a CoA: claiming to conduct 3rtd party tests is one thing, and proving it is another. The CoA should speak for the product and confirm the brand's accuracy, transparency, and reputation.
    • Contaminant purity; the CoA indicates whether the CBD topical passed contaminant tests, also revealing the product's safety profile.
    1. The cannabinoid profile; if you choose full- or broad-spectrum CBD topical, the CoA should indicate the cannabinoid profile of the product, i.e., the cannabinoids present in the time and their relative abundance.
    2. Expiration dates; if you don’t use CBD topicals regularly but want to stock a CBD cream or ointment for occasional use, read the labels to ensure your product has the longest expiration duration since you don’t want it to lose value without exploring it to the best.

    Where Can You Use CBD Topicals for Pain?

    Eskander et al. (2020) noted that CBD topicals may help relieve pain. Where, though, can you apply the topical CBD products and take advantage of their pain-relieving benefits? Generally, CBD studies are limited, and we have to figure out many things independently. In the case of Hammell et al. (2016), where transdermal CBD demonstrated powerful anti-inflammatory benefits, the rats benefited from the application of CBD on the limbs. Besides, Eskander et al. (2020) earlier quoted found CBD topicals good for back pain. The studies show that legs, back, joints, and muscles can all benefit from CBD topicals. Besides, Baron et al. (2018) looked at CBD for headaches and recorded positive results, showing that localized areas around the head can also benefit from CBD topicals.

    What is the Best Time to Apply CBD Topicals?

    CBD creams, ointments, massage oils, and roll-ons are among the commonest topical products people go. One question that one may ask regards when the best time for applying CBD topicals is. There are currently no recommendations on how much CBD to apply or when best to apply the cannabinoid. You somewhat have to figure it out by yourself. For the most part, when best to apply CBD topicals depend on why you are using the cannabinoid.

    While others may use CBD products for fun, most users believe in CBD benefits and look for them in CBD topicals. Ultimately, when to apply CBD topicals is about why use the topicals in the first place. If you want CBD for your well-being, especially when you have joint issues, you may adopt a routine where you apply the cannabinoid at specific times of the day, say at the start of the day or when you are going to sleep. The same is true if your CBD topicals help you manage a medical condition like arthritis. Meanwhile, if you are active in the sports world, you can apply CBD topicals after workouts. Generally, you choose when best to apply CBD topicals, depending on why you are using them.

    What Is the Correct Way to Apply CBD Pain Relief Cream?

    There is no formula for applying CBD pain relief cream and other ointments. Unlike other CBD delivery methods that require you to take a certain amount of CBD oils or a particular number of CBD gummies, there is no recommendation for CBD creams. Like any other topical product, keep the surface or the localized spot to which you want to apply CBD clean, and wipe it dry. Put a little cream on your hand and rub it on the affected area. Massage the spot gently, covering the entire circumference of the pain. You can rub the point as much as it feels good, and there is no exact period you should take massaging the affected area.

    Can CBD Pain Relief Cream Help with Sports Injuries?

    Vučković et al. (2018) reported that CBD can fight chronic pain, including neuropathic, fibromyalgia, and cancer pains. People look for such effects in CBD topicals. Sadly. According to Mauer et al. (2020), most studies have not focused on the sports and athletic populations. While CBD websites claim that the products they offer are good for sports injuries, there is hardly any proof of this. Sports and active people use CBD topicals and apply them to the affected area when they suffer injuries. Meanwhile, we look forward to more CBD studies to provide compelling evidence to show that sports injuries can get better with CBD topicals.

    Can CBD Pain Relief Pain Cream Help with Neck Pain?

    Neck pains are among the most uncomfortable pains since you can barely turn around. Yet, they are common, and the slightest thing like sleeping on the wrong side of the body or carrying heavy things may trigger them. While others may disappear as fast as they came, some neck pains last longer. Can CBD pain relief cream help your neck pain? According to Eskander et al. (2020), CBD topicals are great for back pain. Inferring from this study, CBD seems to have the potential to help body parts relieve pain, and the neck may also benefit from it.

    How Does CBD Pain Relief Cream Work for Back Pain?

    According to Eskander et al. (2020), CBD topicals help relieve back pain. Besides, other studies, including Mlost et al. (2020) and Schilling et al. (2021), confirm that CBD has pain-relieving properties. While there might be substantial reasons to believe this, many wonder how the creams work to relieve pain. Much is yet to be clear about CBD, but studies like Mechoulam & Parker (2013) and Zou & Kumar (2018) report that the body has an endocannabinoid system comprising endocannabinoids, enzymes, and receptors all over the body. The receptors are the CBD targets, and their interaction with the cannabinoid explains all the benefits linked to CBD. Nevertheless, more studies are needed, specifically on how CBD in the creams interact with the receptors and positively influence pain.

    How Much CBD Pain Cream Should You Apply (CBD Pain Relief Cream Dosage)?

    Since the FDA does not control the production of non-prescription CBD like the CBD creams and ointments at CBD dispensaries, it does not recommend how you need to go about the topicals, including how much to apply. As such, the CBD cream experience varies from one person to another, and what works for one CBD fan might not work for me. Here are points that guide CD topical dosage;

    1. How fast it takes to feel better; even without CBD cream dosage recommendation, you can tell when the affected part has had enough of the cream, at which you should apply the topical no more.
    2. Previous CBD experience; using CBD creams for the first time may mean applying more of the cannabinoid to feel the effects. Meanwhile, if CBD topicals are part of your regimen, you may feel the effects fast.
    • The CBD potency of the topical product; generally, more potent CBD products result in fast results. You will not have to apply too much of the cream. However, low-potency creams might take time to produce results, so you may need to apply a little more cream.
    1. The goal behind the CBD cream application; why you apply CBD cream matters. CBD for well-being might take only a little CBD, but applying the cream to fight serious pains might take consistent application per session.

    Which Potency of CBD Cream Should I Focus on?

    There are no one-potency-fits-all options for CBD products, including CBD topicals. The CBD concentration choice for any CBD products largely depends on the following factors;

    1. CBD history; the more you use CBD, the more the body gets used to it. Consequently, low-potency CBD products fit you best when starting out the CBD regimen. If the products work, you might keep them there, but if you don't feel the effectiveness, you can consider higher potencies as time goes by.
    2. The reason for taking CBD; applying topical CBD creams for general fitness might not call for higher-potency CBD products. Meanwhile, managing serious pains with CBD topical products might need higher CBD potencies.
    • The severity of the condition; how severe your condition is directly influences what potency you want to go for. For instance, you can buy low- or medium-potency CBD topicals to help you with random pains. Philpott et al. (2017) reported that CBD can help with chronic pain and should you want CBD topicals for severe chronic pains, higher potencies sound more effective.

    How Long Does CBD Cream Take to Work?

    How long will CBD creams take to work? Will you wait for 5 minutes and feel the effects? Generally, CBD topicals are among the slowest CBD products in action, and they need patience for the effects to manifest. In fact, you can wait for 45- 60 minutes or more before the effects can manifest. Like CBD dosage and potency, how long a CBD cream takes is not the same for everyone. It depends on many factors, including;

    1. CBD potency; while you need not go for high-strength CBD creams when you are just starting out on the cannabinoid, you need to know that the CBD potency of the topicals plays a role in action time. Higher-potency products mean that the molecules are more versatile, active, and potent, so the effects may manifest fast.
    2. How much CBD you apply; you can look forward to CBD effects fast if you apply just what the body needs for the cannabinoid to take effect. Meanwhile, applying too little CBD, especially low-potency and quality types, might leave you waiting for long for the effects.
    • The quality of the CBD cream: quality is like potency and also affects how long it takes CBD topicals to work. High-quality CBD creams deliver the exact amount of CBD indicated on the labels, and if your long CBD experience has helped you gauge your body's CBD needs, the effects will manifest fast.
    1. How the CBD reaches the body; you can use CBD topicals by applying them transdermally or topical. While transdermal CBD application is not common, it delivers CBD fast, allowing you to feel the effects in no time. Meanwhile, topically applying CBD creams may leave you waiting longer for the effects.

    How Long Do CBD Pain Relief Cream and Topical Effects Last?

    Once the CBD cream effects have manifested, you may want to know how long they will take. Will they disappear as fast as they came, or will they last long? Generally, CBD topicals take time to produce effects, taking longer. Yes, you need more patience to feel CBD effects when you administer CBD creams topically than when you take CBD oils and tinctures orally or sublingually. Yet, the former allows the effects to last longer. That said, here are factors that determine how long CBD effects will last in the case of CBD creams;

    1. How much CBD cream you apply; sometimes, CBD effects are biphasic and will not depend on the amount of the cannabinoid. Still, you can expect the effects to last longer if you apply more cream than when you put just a little.
    2. How long the effects took to manifest; if the CBD effects took a short time to manifest, you could expect them to disappear fast. Meanwhile, CBD effects that take time to show may last long.
    • The potency of the CBD cream; how potent your CBD cream is also determines how long the effects will last. Generally, stronger CBD products produce more long-lasting effects than low-potency CBD items, CBD creams and topicals included.
    1. Previous CBD experience; if you have been using CBD topicals for some time, the system gets used to them and breaks the CBD molecules fast. Yet, the faster the effects take to manifest, the shorter they will last, all other factors left constant.

    Are CBD Topicals Good for You?

    The hype and craze on CBD products have been there for the longest time, even when the cannabinoid remained largely illegal and under the radar. The media is now full of information about what CBD can do, and the CBD popularity is never trimming down any soon. Should you try CBD topicals? Are they good for you? Corroon & Phillip (2018) reported that CBD boasts a good safety profile, suggesting that the cannabinoid is largely safe? How true is this?

    According to Velaquez-Manoff et al. (2019), CBD promises a lot but may have many adverse effects, although their degrees vary from one brand to the other. The safety concerns of CBD products, including CBD topicals, are cropping up daily because the CBD market is largely unregulated. Meanwhile, there are serious knowledge gaps in the CBD arena, and even when we have many research papers to refer to and give accolades to CBD topicals for this or that, they admit that more studies are needed to prove their claims. Bodies like the FDA that would set things right in the CBD world have stood on the fence and take no responsibility for CBD production. Meanwhile, CBD users struggle to determine the right potencies for CBD topicals and how much CBD to apply. Examine all these factors before settling for CBD topicals or any other CBD-infused item.


    CBD topicals include creams, lotions, massage oils, and roll-ons applied to external body parts. They are among the many ways through which CBD gets to the body. They may not be as bioavailable as CBD oils, tinctures, or vapes, but they are still good if you need CBD but not its interaction with the bloodstream. There are three types of CBD topicals, including isolate-based, full-, and broad-spectrum formulated options, depending on what they are made of. Although early studies claim that CBD topicals may help with pain and inflammation, more research with compelling scientific evidence is needed to prove this. CBD topicals are applied topically or transdermally, where the latter allows more effectiveness.

    Although full-spectrum CBD topicals may have THC, they will not get you 'high' or make you fail drug tests since the THC does not interact with the bloodstream. How much CBD in the topicals you can apply, how long they take to work, and how long the effects last depend on many factors, touching on the user and the topical product.


    American Academy of Dermatology. (Feb 2018). Public researchers demonstrate growing interest in cannabis treatment. Topical application shows promise for skin diseases.

    Arthritis Foundation CBD Guidelines for Adults with Arthritis.

    Baron, E. P. (2018). Medicinal properties of cannabinoids, terpenes, and flavonoids in cannabis, and benefits in migraine, headache, and pain: an update on current evidence and cannabis science. Headache: The Journal of Head and Face Pain, 58(7), 1139-1186.

    Bass, J., & Linz, D. R. (2020). A case of toxicity from cannabidiol gummy ingestion. Cureus, 12(4).

    Bauer, B. A. (2020). What Are The Benefits Of CBD–And Is It Safe To Use?. In Mayo Clinic.

    Centers for Disease Control and Prevention. (2020). Outbreak of lung injury associated with the use of e-cigarette, or vaping, products.

    Corroon, J., & Phillips, J. A. (2018). A Cross-Sectional Study of Cannabidiol Users. Cannabis and cannabinoid research3(1), 152–161.

    Eskander, J. P., Spall, J., Spall, A., Shah, R. V., & Kaye, A. D. (2020). Cannabidiol (CBD) as a treatment of acute and chronic back pain: A case series and literature review. J Opioid Manag, 16(3), 215-8.

    Gill, L. (2020). A Guide to CBD and Cannabis for Older Adults. More people are using these substances for problems like pain. But what does the science say? In the Consumer Report Survey.

    Hammell, D. C., Zhang, L. P., Ma, F., Abshire, S. M., McIlwrath, S. L., Stinchcomb, A. L., & Westlund, K. N. (2016). Transdermal cannabidiol reduces inflammation and pain-related behaviours in a rat model of arthritis. European journal of pain (London, England), 20(6), 936–948.

    Huestis, M. A., Solimini, R., Pichini, S., Pacifici, R., Carlier, J., & Busardò, F. P. (2019). Cannabidiol adverse effects and toxicity. Current Neuropharmacology, 17(10), 974-989.

    Iffland, K., & Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and cannabinoid research, 2(1), 139–154.

    Karniol, I. G., Shirakawa, I., Takahashi, R. N., Knobel, E., & Musty, R. E. (1975). Effects of delta9-tetrahydrocannabinol and cannabinol in man. Pharmacology13(6), 502–512.

    Massi, P., Vaccani, A., Bianchessi, S., Costa, B., Macchi, P., & Parolaro, D. (2006). The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells. Cellular and Molecular Life Sciences CMLS, 63(17), 2057-2066.

    Maurer, G. E., Mathews, N. M., Schleich, K. T., Slayman, T. G., & Marcussen, B. L. (2020). Understanding cannabis-based therapeutics in sports medicine. Sports Health, 12(6), 540-546.

    Mechoulam, R., & Parker, L. A. (2013). The endocannabinoid system and the brain. Annual review of psychology, 64, 21-47.

    Meissner, H., & Cascella, M. (2021). Cannabidiol (CBD). In StatPearls [Internet]. StatPearls Publishing.

    Mlost, J., Bryk, M., & Starowicz, K. (2020). Cannabidiol for pain treatment: focus on pharmacology and mechanism of action. International journal of molecular sciences, 21(22), 8870.

    Murillo-Rodríguez, E., Sarro-Ramírez, A., Sánchez, D., Mijangos-Moreno, S., Tejeda-Padrón, A., Poot-Aké, A., Guzmán, K., Pacheco-Pantoja, E., & Arias-Carrión, O. (2014). Potential effects of cannabidiol as a wake-promoting agent. Current neuropharmacology, 12(3), 269–272.

    Nitecka-Buchta, A., Nowak-Wachol, A., Wachol, K., Walczyńska-Dragon, K., Olczyk, P., Batoryna, O., Kempa, W., & Baron, S. (2019). Myorelaxant Effect of Transdermal Cannabidiol Application in Patients with TMD: A Randomized, Double-Blind Trial. Journal of clinical medicine8(11), 1886.

    Philpott, H. T., O'Brien, M., & McDougall, J. J. (2017). Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain, 158(12), 2442–2451.

    Schilling, J. M., Hughes, C. G., Wallace, M. S., Sexton, M., Backonja, M., & Moeller-Bertram, T. (2021). Cannabidiol as a Treatment for Chronic Pain: A Survey of Patients' Perspectives and Attitudes. Journal of pain research, 14, 1241–1250.

    Schlienz, N. J., Lee, D. C., Stitzer, M. L., & Vandrey, R. (2018). The effect of high-dose dronabinol (oral THC) maintenance on cannabis self-administration. Drug and alcohol dependence, 187, 254-260.

    Schuelert, N., & McDougall, J. J. (2011). The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55. Neuroscience Letters, 500(1), 72–76.

    VanDolah, H. J., Bauer, B. A., & Mauck, K. F. (2019, September). Clinicians’ guide to cannabidiol and hemp oils. In Mayo Clinic Proceedings (Vol. 94, No. 9, pp. 1840-1851). Elsevier.

    Velasquez-Manoff, M. (2019). Can CBD really do all that. The New York Times.

    Vučković, S., Srebro, D., Vujović, K. S., Vučetić, Č., & Prostran, M. (2018). Cannabinoids and pain: new insights from old molecules. Frontiers in pharmacology, 1259. 

    Watt, G., & Karl, T. (2017). In vivo evidence for therapeutic properties of cannabidiol (CBD) for Alzheimer's disease. Frontiers in pharmacology, 8, 20.

    Weydt, P., Hong, S., Witting, A., Möller, T., Stella, N., & Kliot, M. (2005). Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival. Amyotrophic lateral sclerosis and other motor neuron disorders: official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases6(3), 182–184. 

    Wong, H., & Cairns, B. E. (2019). Cannabidiol, cannabinol, and their combinations act as peripheral analgesics in a rat model of myofascial pain. Archives of oral biology104, 33–39.

    Xu, D. H., Cullen, B. D., Tang, M., & Fang, Y. (2020). The Effectiveness of Topical Cannabidiol Oil in Symptomatic Relief of Peripheral Neuropathy of the Lower Extremities. Current pharmaceutical biotechnology21(5), 390–402.

    Zou, S., & Kumar, U. (2018). Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. International journal of molecular sciences, 19(3), 833.

    Zurier, R. B., & Burstein, S. H. (2016). Cannabinoids, inflammation, and fibrosis. The FASEB Journal, 30(11), 3682-3689.