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Endocannabinoid System and CBG

September 15, 2022 4 min read

 Endocannabinoid System and CBG

Endocannabinoid System and CBG

Canaigre interacts with the endocannabinoid receptors to relieve pain, reduce inflammation, suppress cancer growth and prevent bacterial infections.

Many compounds in the plant are associated with different health benefits such as pain relief, sleep improvement, and anti-inflammation. The cannabis plant contains many compounds, including cannabinoids, terpenes, and flavonoids. Cannabidiol, tetrahydrocannabinol, and canaigre are the most common cannabinoids of the plant. The compounds are infused in many products making them easily available for consumers. Like CBD, CBG works by binding the ECS receptors to strengthen anandamide functioning. The anandamide neurotransmitter is essential for regulating sleep, appetite, pain alleviation, and enhancing pleasure.

What Is CBGA and the Endocannabinoid System

CBGA is commonly known as the mother of all cannabinoids since other cannabinoids are derived from it. The cannabis derivative is an acidic compound. Just like other cannabinoids, CBG is derived from the cannabis and hemp plant. CBG is among the most known cannabinoids after CBD and THC. It is non-psychoactive and cannot affect the mental functioning of the user.

THC is the most common compound derived from marijuana and has psychoactive properties. The hemp plant contains a high amount of the medicinal CBD. It is thus legalized by the food and drug administration since it is considered safe for use.

Much research has recently been carried out on the golden specimen since the compound has therapeutic effects on the body. The hemp plant contains very compositions of hemp. CBG is found in high amounts in the young cannabis plants compared to fully grown ones. As hemp matures, the CBDA is converted to CBD and THC. However, cannabis farmers are trying different ways to increase the amounts of CBG through cross-breeding and genetic manipulation.

 CBG works by interacting with the endocannabinoid system. The endocannabinoid system includes the nerves, brain, and skin. The cannabinoid receptors are divided into CB1 and CB2. The CB1 receptors are in the nerves and the brain, while CB2 are domiciled in the immune system. CBG interacts with endocannabinoid receptors by binding the CB1 and CB2 receptors, correcting irregular body functions.

The body’s endocannabinoid receptors have the same molecular structure as the ones found in plants. The receptors are responsible for well-functioning the immune system, regulating appetite and senses, and balancing the internal and external body environments.

How CBG Is Made

 CBG is majorly derived from young cannabis plants. There are three types of cannabis CBG strains; white CBG, glue CBG, and jack frost CBG, which have more CBG compounds than other cannabinoids. The main reason for the cultivation of these strains is to produce CBG.

 CBG and CBD are developed from CBDA. Due to the scarcity of CBG, many cannabis growers have been trying to figure out methods to increase the compound's production by cross-breeding and genetic modification.

Health Benefits of CBG

 CBD and CBG have more similarities than differences. Like CBD, CBG can help the body in different ways without intoxication. Different researches support the ability of CBG to offer therapeutic effects, but they are limited to animals. Therefore, there is a need for more research on human beings. Some of the therapeutic benefits of CBG include;

Huntington’s disease

Different health conditions affect the nerves. Huntington’s diseases result in the breakdown of the brain nerve cells. According to Míčka (2013), CBG can form a protective gear, thus preventing the damage of the brain's nerve cells and promoting motor coordination.


 Inflammation can cause too much discomfort affecting your daily activities and productivity. Most inflammation is accompanied by pain. According to Hill et al. (2016), CBG has an anti-inflammatory effect and thus can be used to treat different health conditions characterized by swelling. For example, inflammatory bowel disease is a health condition causing severe swelling in the bowel. The condition is incurable. Research suggests that patients' IBD significantly reduced pain after CBG administration.

Pain Alleviation

 Any form of pain can affect your daily life. This can limit you from reaching your full potential. Pain can impact your sleep pattern and cause insomnia. Acute or chronic pain can affect your productivity. Most over-the-counter painkillers like opioids are effective for pain reduction. However, they tend to have side effects such as headaches and addiction. According to Überall (2020), cannabinoids can naturally ease muscle pain, joints, and nerve pain since they have a soothing and relaxing effect on the body and the brain.

Fighting Cancer Cells

 According to Lu et al. (2017), CBG could block the growth of cancer-causing receptors. It can suppress cancer by inhibiting its multiplication and spread. Therefore, it is believed that CBG can help cure and treat colon cancer.

Antibacterial Property

The body is exposed to different disease-causing organisms, including bacteria and fungi. Research associated cannabis with antibacterial, antibacterial properties. Aqawi et al. (2021) showed that CBG can prevent and treat different bacterial infections. For instance, it prevents staph infection, which is generally resistant to drugs. Similarly, it can treat skin infections, including eczema and psoriasis, when used topically. 


CBG is majorly derived from young cannabis plants. The cannabis derivative became popular in the market due to its health-associated benefits. CBG works synergistically with other cannabinoids to provide a wider range of effects. Although cannabinoids' effects do not have a scientific backup, they have proven reliable based on customer reviews and clinical observation. CBG has diverse properties such as anti-inflammatory, antibacterial, and the ability to relieve pain and inflammation.



Aqawi, M., Sionov, R. V., Gallily, R., Friedman, M., & Steinberg, D. (2021). AntibacterialAntibacterial properties of cannabigerol toward Streptococcus mutans. Frontiers in Microbiology, 12, 656471.

Hill, L. A., Bodnar, T. S., Weinberg, J., & Hammond, G. L. (2016). Corticosteroid-binding globulin is a biomarker of inflammation onset and severity in female rats. The Journal of endocrinology, 230(2), 215.

Lu, X. S., Qiao, Y. B., Li, Y., Yang, B., Chen, M. B., & Xing, C. G. (2017). Preclinical study of cinobufagin as a promising anti-colorectal cancer agent. Oncotarget, 8(1), 988.

Míčka, T. (2013). Getting High to Get Well: Scientific Evidence of Therapeutic Uses of Cannabinoids and Terpenoids.

Überall, M. A. (2020). A review of scientific evidence for THC: CBD oromucosal spray (nabiximols) in chronic pain management. Journal of pain