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  • August 17, 2022 4 min read


    Preliminary studies show that CBD is effective against mental issues such as depression, anxiety, schizophrenia, and insomnia forms of dementia. In addition, Cannabidiol is effective against multiple skin issues such as acne, aging, inflammation, and psoriasis. However, it is important to distinguish between CBD and THC. The two are different compounds. Legally, tetrahydrocannabinol THC is classified as illegal as it is addictive and induces psychosis in its users. In addition, THC is mainly produced by marijuana, whereas CBD is only harvested from hemp, which has very low levels of THC. Together, these compounds constitute at least forty percent of cannabis-related plants' cannabinoids.

    How CBD Works

    The human body is endowed with two parallel systems that work hand in hand to perform homeostatic functionsin the body. These are the central nervous system and the endocannabinoid system. In particular, the Endocannabinoid system is important as it is responsible for various functions such as inhibiting or enhancing connections between nerve cells, controlling the body temperature, and controlling the body's immunity response. CBD interacts with the body through CB1 and CB2 receptors spread out in the body. CB1 receptors are mainly found in the brain and regulate the production of various hormones, affecting the body in different ways. CB2 receptors are found in the body and are partly responsible for the body's immune response against various pathogens. However, the effectiveness and the time it takes for CBD to take effect depends on the users' method of administration and the form of CBD it is administered. CBD majorly takes the form of vaporizers, tinctures, oils, edibles, topicals, and pills and capsules. Each method affects the time it takes to take effect, as each takes different routes to reach the endocannabinoid system. In addition, there are three types of CBD extracts, i.e., full-spectrum CBD, broad-spectrum CBD, and CBD isolates. These vary in CBD concentration, with isolates being a pure form of CBD. Below is a discussion of each type and how long it takes to affect the user.

    Sublingual Administration Of CBD

    It is one of the most common and effective methods of taking CBD. It entails putting a few drops of CBD oil under your tongue and allowing the compound to dissolve and diffuse into your bloodstream via the tissues in your tongue. It is similar to buccal administration in many ways. It is where you put a substance between your gums and your cheek. By doing so, you allow the substance to dissolve and diffuse into your bloodstream. When consuming CBD spray, you can use buccal administration. Oils, sprays, tablets, and films are all examples of sublingual and buccal substances. CBD oil has a 13-19% absorption rate with a few small drops under the tongue when administered sublingually.CBD oil has been shown to have up to 35% sublingualbioavailability in some circumstances. Vaping CBD isn't for everyone, and sublingual CBD absorption rates are significantly higher than those of orally ingested CBD products. Most CBD products are taken sublingually to reach maximum blood levels within 10-15 minutes. Following this point, the amount of the substance in your bloodstream gradually decreases. When consumers require a quick onset of action, sublingual administration is advantageous. It is unlikely that you will experience immediate therapeutic effects after ingesting CBD oil. However, the rate at which you experience therapeutic benefits is likely to be faster than if you used orally ingested CBD products such as CBD edibles.

    Oral Administration Of CBD

    Cannabidiol delivered in this manner remains in the body for a long time – it can take up to 5 days for consistent reception (it works for about 3-4 hours on a one-off basis). However, oral administration in capsules, for example, has numerous drawbacks. It takes much longer to be absorbed than other administration routes (the maximum concentration is reached after about 3 hours). Second, and most importantly, due to the obstacles, it must overcome. When CBD passes through our digestive system, a large portion of it degrades.

    Oral Mucosal Administration

    Sprays and CBD oils are both included in this category. The key here is direct contact with the oral mucous membranes. Because these areas are extremely well supplied with blood, the active substance can enter the bloodstream and reach its maximum concentration in the plasma in a relatively short period. Unfortunately, it also leaves our bodies quickly – CBD levels drop by half after 1.5 – 11 hours (considerable variation results from individual differences between people). The bioavailability of Cannabidiol, in this case, is high due to the presence of high-quality oil and an appropriate area of administration.

    Inhalation of CBD

    CBD can be inhaled using a vaporizer, which is a specialized device. The CBD concentrate or hash is heated to the temperature at which the active ingredient is released. However, because this temperature never reaches the combustion temperature, Cannabidiol released in this manner is inhaled as a vapor rather than smoke. Smoking CBD-infused dried cannabis is slightly less effective. When exposed to high temperatures, a large portion of Cannabidiol degrades, lessening our bloodstream. However, this is the quickest way to deliver CBD to the body – peak concentrations are observed after about 3 minutes. The absorption rate of CBD is much higher when it is inhaled using products such as vape pens. CBD absorption rates via intranasal administration can range from 34 to 46 percent. As a result, the efficacy of CBD vape pens can vary greatly. According to some studies, the rate can reach 56%.


    CBD can be administered via the oral route, sublingually, topical creams, and vaporizers, among other administration forms. The quickest way of administration is through the intranasal route using vapes and intranasal sprays. Oral administration takes the longest to take effect, averaging around three hours and lasts up to eleven hours after administration. Thus, it is suitable when looking for a long-lasting method. However, the rate of effectiveness of CBD is also affected by the individual's weight, age, and sex. Keep in mind the lipophilicity of CBD as it is significantly bioavailable when consumed with fats, facilitating its distribution around the lymphatic system.


    Campos, A. C., Moreira, F. A., Gomes, F. V., Del Bel, E. A., & Guimaraes, F. S. (2012). Multiple mechanisms are involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders. Philosophical Transactions of the Royal Society B: Biological Sciences, 367(1607), 3364-3378.