The cannabis plant's capacity to create a wide range of chemical compounds is one of the primary reasons for its vast applications. In reality, Cannabis contains more than 500 distinct compounds. The cannabinoids include CBDV, CBG, CBN, CBGV, and CBTV.
While some are found in many different plants, such as terpenes and flavonoids (the molecules responsible for the flavor and aroma of Cannabis), others are unique to Cannabis. Cannabinoids, on the other hand, are prevalent in the cannabis plant, where they are found in far greater concentrations than the rest of nature's cannabinoids. Tetrahydrocannabinol (THC) is responsible for the therapeutic properties of Cannabis as well as its intoxication effects. Cannabidiol (CBD) is another well-known cannabinoid that has been lauded for its therapeutic properties without the high. Cannabinoids other than THC and CBD are prevalent in the cannabis plant, although they are less widely understood.
According to Moreno et al. (2020), heating cannabis acids (decarboxylating) yields the chemicals most users want (THC or CBD). Cannabis can also manufacture other closely related cannabinoid acids besides THCA and CBDA. Cannabigerovarinic acid (CBGVA), Tetrahydrocanabivarinic acid (THCA), CBDVA (Cannabidivarinic acid), CBCVA (Cannabichromevarinic acid), and THCVA (Cannabigerovarinic acid) are some of the more common cannabinoids. There are several cannabinoid acids, each of which may be decarboxylated into a specific cannabinoid. Cannabinoids such as THCA and CBDA are the most commonly found in cannabis strains. The additional elements depicted are often found at considerably lower concentrations. Chemically, the most important cannabinoid acids are CBGA, THCA, CBDA, and CBCA (in that order). The plant's enzymes use CBGA as a starting point to produce the other three. CBGVA, THCVA, CBDVA, and CBCVA are just a few of the "V" compounds with somewhat shorter chemical structures that are also available. Cannabinoid acids, unlike THC, are not known to have intoxicating effects. They possess several intriguing characteristics. Many cannabinoid acids have antibacterial or insecticidal properties. For example, Cannabis creates these substances to protect itself, which is likely why.
What are the "Minor Cannabinoids"?
Cannabis also contains minor cannabinoids, albeit in fewer concentrations than the major ones. Because humans are so adept at breeding specialized strains, it's getting increasingly impossible to distinguish between minor and major cannabinoids. Most cannabinoids can be found in these strains; however, some are simpler to mass-produce than others.
CBDV may be of interest to those who like the effects of CBD. Similarly, in structure to the cannabinoid cousin CBD, this molecule doesn't alter your perceptions or your capacity to work properly. It's not a well-studied cannabinoid, although a few studies have highlighted its possible therapeutic use. According to Hill et al. (2013), CBDV can be an anticonvulsant for people with epilepsy and other neurological diseases. In one research, it was proven to reduce seizures, and GW Pharmaceuticals is presently testing an epileptic medication derived from CBDV. There is some evidence that CBDV, studied in the British Journal of Pharmacology, may be beneficial for relieving nausea in rats.
Histamine-binding cannabinoid CBG is widely distributed in hemp and marijuana plants. The non-psychoactive cannabinoid it contains is an excellent alternative. Even though CBG is not psychoactive, it has a wide range of therapeutic benefits. Dawidowicz et al. (2021) noted that CBG effectively treats various ailments. The anti-inflammatory and pain-relieving properties of CBG make it a popular choice. It has been found to induce neurogenesis, the growth of new brain cells, and function as a neuroprotectant against degeneration in disorders like Huntington's disease. Cancers of the colon, prostate and oral cavity may benefit from CBG treatment. Aside from treating glaucoma, psoriasis, and other skin conditions, it can also act as an effective antibacterial agent, regulate emotions like an antidepressant, and be effective against drug-resistant bacteria like MRSA.
Renowned for its pain-relieving and anti-inflammatory effects, this non-psychoactive cannabinoid also contains a few lesser-known qualities. Toth et al. (2019) concluded that among cannabinoids, CBGV had been found to treat dry skin, which is unusual. As a cancer therapy, CBGV has also shown promising results. It has even been observed that CBGV suppresses the development and division of leukemic cancer cells in research published in Anticancer Research.
As the cannabinoid produced as THC matures, CBN was previously known as cannabinol. Many individuals choose older Cannabis because of the higher concentrations of cannabinoids like CBN, even though it doesn't taste as good. CBN may or may not be the appropriate cannabinoid for you, depending on your desired effects. Many people mistakenly believe that CBN is a sedative, but this is not the case. With THC, pure CBN has no effect, but the combination is extremely soothing. People living with Insomnia might benefit from a high concentration of CBN and THC in Cannabis. CBN has also increased hunger, relieved glaucoma, and acted as a potent antibacterial.
Another cannabinoid, CBC, has a variety of beneficial benefits. Resistance-resistant infections can be helped by both CBN and CBC, potent antibiotics. When combined with THC, CBC has pain-relieving, mood-boosting, and inflammation-reducing properties. Infections showing resistance to conventional antibiotics respond well to CBC, a potent antibiotic. Goyal et al. (2014) established that CBC might assist protect the brain against neurodegenerative diseases like Alzheimer's. In addition to protecting the brain, CBC supports the growth of new brain cells in specific regions linked to memory and learning, according to Some believe that CBCV, a chemical related to CBC, has the same effects as CBC. The study on this Cannabis isn't sufficient to prove any specific medicinal benefits, which is a bummer.
The article has only scratched the surface of what cannabinoids can do. Research into these amazing chemicals has only just begun, and there are still many more cannabinoids to be discovered and discovered about to be discovered. This should provide enough information to begin the search for the right cannabinoids as a starting point. It's possible to learn how to identify the cannabinoids that work best for you and ignore the ones that often don't.
Dawidowicz, A. L., Olszowy-Tomczyk, M., & Typek, R. (2021). CBG, CBD, Δ9-THC, CBN, CBGA, CBDA And Δ9-THCA As Antioxidant Agents And Their Intervention Abilities In Antioxidant Action. Fitoterapia, 152, 104915.
Goyal, M. S., Hawrylycz, M., Miller, J. A., Snyder, A. Z., & Raichle, M. E. (2014). Aerobic Glycolysis In The Human Brain Is Associated With Development And Neotenous Gene Expression. Cell Metabolism, 19(1), 49-57.
Hill, T. D. M., Cascio, M. G., Romano, B., Duncan, M., Pertwee, R. G., Williams, C. M., ... & Hill, A. J. (2013). Cannabidivarin‐Rich Cannabis Extracts Are Anticonvulsant In Mouse And Rat Via A CB1 Receptor‐Independent Mechanism. British Journal Of Pharmacology, 170(3), 679-692.